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What Makes Isotonix® Resveratrol Unique?
Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume or, more importantly, an extract found in red wine: resveratrol. Resveratrol is an ingredient with incredible clinical research, revealing that it supports cardiovascular and normal cell health. Because wine is so highly processed, the actual amount of resveratrol is quite low. One would have to drink at least three bottles of red wine a day to experience the effects of resveratrol extract. Additionally, the content of resveratrol in red wine is inconsistent and varies by type of wine, region and processing techniques. Resveratrol extract or more specifically, Resveravine®, which is a more concentrated form of resveratrol, ensures that the body reaps all of the benefits of resveratrol, without the ill effects from three bottles of wine.*
Isotonix® Resveratrol is an isotonic-capable supplement, made from three patented ingredients: Resveravine with 20% resveratrol extract, BioVin® Advanced with 5% resveratrol extract, and VitaBlue® (wild blueberry extract), designed to promote normal cell health. Isotonix Resveratrol works to maintain cell health, promote normal cell cycle activity, promote apoptosis (programmed cell death) in unhealthy cells, support the normal activity of the SIRT-1 gene, and promote cardiovascular health, by promoting healthy platelet activity, promoting vasorelaxation, and providing antioxidant protection of LDL particles. Resveravine is a combination of trans-resveratrol (20% purity) and viniferin extracted from vine stems, which work synergistically to enhance the effectiveness of resveratrol extract. Trans-resveratrol is the predominate isomer found in red wine grapes and juice, and Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products from grape skin. According to the Linus Pauling Institute at Oregon State University, trans-resveratrol may have a higher bioavailability than other isomers of resveratrol. Resveravine provides a higher level of free radical defense against oxidative stress, stronger promotion of normal cellular activity, and higher antioxidant protection of LDL particles than pure resveratrol extract.*
Studies of numerous species have shown that a reduction in calories has been linked to a longer lifespan. The SIRT-1 gene activates a critical component of calorie restriction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.
Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Primary Benefits of Isotonix® Resveratrol*:
- Maintains cell health
- Promotes normal cell cycle activity
- Promotes apoptosis (programmed cell death) in unhealthy cells
- Promotes normal nuclear factor kappa B (NF-Kappa B – protein) and cyclooxygenase-2 (COX-2 - enzyme) activity
- Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)
- Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles).
- Superior antioxidant and high ORAC value
- Promotes a healthy prostate gland
- Helps promote apoptosis in unhealthy prostate cells
Key Ingredients Found In Isotonix® Resveratrol:
Resveravine® (20% resveratrol extract): 10 mg
Resveratrol is a natural antioxidant found in red wine. Resveravine is a natural extract from Vitis vinifera standardized to contain 20% oligostilbenes. Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products made from grape skin. It provides antioxidant protection of low-density lipoprotein (LDL) particles, promotes normal platelet activity, vasorelaxation and blood flow, all which support cardiovascular health. It has been shown to promote apoptosis (programmed cell death) in unhealthy cells. Another proposed mechanism of action involves the study of the SIRT-1 gene (also known at the longevity gene). Sirtuins, known as Silent Information Regulators (SIRs), are deacetylase enzymes identified in all living creatures. Sirtuin proteins are known to play an important role in keeping regions of chromosomes turned off. Sirtuin controls the enzyme that converts acetate, a source of calories, into acetyl-CoA, a key component of cellular respiration. In humans, there are seven different sirtuins, SIRT-1 to SIRT-7. SIRT-1 has been studied by scientist for its potential effect on human cell lifespan.*
Resveratrol promotes normal activity of SIRT-1. Studies have shown that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization. The most recent study (Nature 2006) demonstrated that obese mice fed red wine extract (resveratrol) were in better health and lived longer than obese mice that were not fed the red wine extract. The resveratrol group, were more able to maintain heart health compared to mice that were not fed resveratrol. SIRT-1 activation also supports healthy mitochondrial function and supports energy expenditure. Resveratrol has also been shown to have phytoestrogen activity and may support optimal estradiol activity. Other studies have documented neuroprotective benefits associated with resveratrol supplementation.*
A comparison test was made to evaluate the activating effect on human SIRT-1 of Resveravine and pure trans-resveratrol. Only the trans-resveratrol form of the molecule promotes normal activation of the mammalian SIRT-1 gene in vitro test. Resveravine was more than eight times more likely to promote SIRT-1 activity than pure trans-resveratrol, showing that Resveravine is more efficient than resveratrol in promoting the normal activity of SIRT-1. Therefore, while the specific mechanisms of SIRT-1 and resveratrol are still unclear, the studies show that SIRT-1 is essential in lifespan extension and health improvement, and resveratrol promotes SIRT-1 activity.*
Studies in numerous species have demonstrated that reduction of calories 30 to 50 percent below ad libitium levels of a nutritious diet can promote a longer lifespan, improve overall health, promote normal stress resistance and decelerate functional decline. Studies showed that, SIRT-1 activates a critical component of calorie restriction in mammals, and promotes fat mobilization in adipocytes by repressing PPAR (test conducted on mice). Because healthy fat levels have been show to promote a longer murine lifespan, it is suggested that calorie restriction could be connected to SIRT-1 and life extension in mammals.
As an alternative strategy, new research has focused on the development of calorie restriction mimetics, compounds that mimic the effect of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake. Resveratrol has been suggested as a potential calorie restriction mimetic.
Supplementing mice with resveratrol significantly increases their aerobic capacity. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting healthy weight. In vivo test conducted on mice on a high-calorie diet, resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and promotes their overall health.
BioVin® Advanced (French Red Wine Extract with 5% resveratrol): 200 mg
Red wine extract containing oligomeric proanthocyanins (OPCs), known to be extremely effective in supporting cardiovascular health by supporting normal blood circulation, strengthening blood vessels, and promoting normal platelet activity. BioVin Advanced provides OPCs and additional Resveratrol. The red wine grape contains two main constituents shown to be of significant antioxidant value: red wine polyphenols (flavonoids) and trans-resveratrol (mentioned above). Oligomeric proanthocyanins are flavonoid complexes that act as super potent antioxidants in the human body. BioVin Advanced combines the antioxidant properties of OPCs with trans-resveratrol to promote phase 2 metabolizing enzymes, which are involved in the detoxification of the body’s cells, promoting apoptosis (programmed cell death) in unhealthy cells, promoting healthy cholesterol levels, and general free-radical scavenging properties.*
VitaBlue® Wild Blueberry Extract (12.5% anthocyanins): 50 mg
Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanin gives blueberries (and other fruits) their rich blue and red coloring, and is a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as the promotion of healthy cells and apoptosis (programmed cell death). Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. VitaBlue Wild Blueberry Extract supports the body’s COX-2 inhibitors and provides powerful antioxidants in much higher quantities than fresh blueberries, and show to be effective in promoting cardiovascular health, contributing to normal cell cycle traverse, and maintaining overall cellular health.*
Frequently Asked Questions About Isotonix® Resveratrol:
Resveratrol contains wine extracts. Is it alcohol free?
Yes. Resveratrol is alcohol free; there is no alcohol in this product.*
I am currently taking medication to manage my cholesterol. Can I still take Resveratrol?
There are no documented interactions with cholesterol medication and any of the ingredients in Resveratrol. However, before taking any natural supplement, you should consult your physician.
Are there any contraindications for Isotonix Resveratrol?
Yes. If you are currently taking warfarin (Coumadin) or other anti-platelet/anti-coagulant, you should not take this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Women who are pregnant or breastfeeding should not take this product.*
Can I take Resveratrol and still have a glass of wine with dinner?
Yes. There is no cause of concern.*
I already take a multivitamin. Why do I need Resveratrol?
Resveratrol is not a multivitamin. It is a product designed to promote optimal cell health and provide cardiovascular support.*
If I am an alcoholic, can I still take Resveratrol even though it is from red wine?
Yes. Isotonix Resveratrol does not contain alcohol. Resveratrol is an extract from grape skins and vines that are used to make red wine.*
Will I get drunk from taking Resveratrol?
No. Isotonix Resveratrol does not contain alcohol.
Is this product vegetarian friendly?
Yes. Isotonix Resveratrol is a vegetarian product.
Who should take this product?
Clinical studies have shown that resveratrol extract may be helpful in promoting apoptosis (programmed cell death) in unhealthy cells, supporting normal cell cycle activity, promoting the normal activity of the SIRT-1 gene, thereby supporting overall cellular health. If you are interested in promoting cellular health and maintaining good cardiovascular health, then Isotonix Resveratrol is perfect for you.*
Can men and women take this product?
Yes. However, women with a history of estrogen-sensitive cancers (breast, ovarian, uterine) should not take this product. Women who are pregnant or breastfeeding should not take this product.*
When should I start to see/feel the effects of this product? What should I expect?
The antioxidant benefits of Isotonix Resveratrol should be noticeable in about four to six weeks. Please remember that everyone’s body is different, so for some it may take longer to notice the benefits of Resveratrol. You should expect to feel better and healthier overall.*
Do I need OPC-3 if I take this product?
Isotonix OPC-3 is a superior antioxidant with many health benefits. Isotonix Resveratrol can be taken with other antioxidants; if fact, antioxidants work in several mechanisms, and they build upon each other. For a complete comprehensive antioxidant defense, taking OPC-3 and Resveratrol is a smart choice protecting your body from the damaging effects of free radicals.*
Scientific Studies Which Support Isotonix® Resveratrol:
- Aggarwal B et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Research. 24(5A):2783-840, 2004.
- Bauer, J. H., et al. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc Natl Acad Sci U S A. 101:12980-12985, 2004.
- Baur J et al. Resveratrol improves health and survival of mice on a high-calorie diet.
Nature. 444(7117):337-42, 2006.
- Belguendouz, L., et al. Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochemical Pharmacology. 53(9):1347-1355, 1997.
- Bhat K et al. Biological effects of resveratrol. Antioxidants and Redox Signaling. 3(6):1041-64, 2001. Review.
- Borra M et al. Mechanism of human SIRT1 activation by resveratrol. Journal of Biological Chemistry. 280(17):17187-95, 2005.
- Chen Y. Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice. Surgery.136(1):57-66, 2004.
- Dario et al. Resveratrol prolongs life span and retards the onset of age-related markers in a short-lived vertebrae. Current Biology, 2006.
- Ding, X. Z., et al. Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Pancreas. 25(4):71-76, 2002.
- Dong Z. Molecular mechanism of the chemopreventive effect of resveratrol. Mutation Research. 523-524:145-150, 2003.
- Donnelly L et al. Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol, 2004 .
- Faria A et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. Journal of Agricultural and Food Chemistry. 53(17):6896-902, 2005.
- Frémont L. Biological effects of resveratrol. Life Sciences 66:663-673, 2000.
- Fremont, L., et al. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sciences. 64(26):2511-2521, 1999.
- Garvin S et al. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Letters. 231(1):113-22, 2006.
- Goh S et al. The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxidant Redox Signal. 9(1):101-13, 2007.
- Hao H et al. Mechanisms of cardiovascular protection by resveratrol. Journal of Medicinal Food. 7(3):290-298, 2004.
- Heynekamp J et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. Journal of Medicinal Chemistry. 49(24):7182-9, 2006.
- Holmes-McNary M and Baldwin A Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Research. 60:3477-3483, 2000.
- Hou D et al. Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins. Journal of Biomedicine and Biotechnology. 2004: (5):321-325, 2004.
- Hou D. Potential mechanisms of cancer chemoprevention by anthocyanins. Current Molecular Medicine. 3(2):149-159, 2003.
- Howitz, K. T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425(6954):191-6, 2003.
- Hung L et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovascular Research. 47:549-555, 2000.
- Hung L et al. Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms. Free Radicals in Biology and Medicine. 36(6):774-81, 2004.
- Hwang J et al. Resveratrol induces apoptosis in chemoresistant cancer cells via modulation of AMPK signaling pathway. Annals NY Academy of Sciences. 1095:441-8,2007.
- Ignatowicz E and Baer W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Polish Journal of Pharmacology. 53(6):557-69, 2001.
- Jang M et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218-220, 1997.
- Jang M et al. Cancer chemopreventive activity of resveratrol. Drugs in Experimental Clinical Research. 25:65-77, 1999.
- Kaeberlein M et al. Substrate-specific activation of sirtuins by resveratrol. Journal of Biological Chemistry. 280(17):17038-45, 2005.
- Kim, Y. A., et al. Antiproliferative effect of resveratrol in human prostate carcinoma cells. Journal of Medicinal Food. 6(4):273-280, 2003.
- Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? European Journal of Endocrinology. 138(6):619-620, 1998.
- Kundu, J. K., et al. Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets. Biofactors. 21(1-4):33-39, 2004.
- Lagouge M et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT-1 and PGC-1alpha. Cell. 127(6):1109-22, 2006.
- Lepoivre M et al. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Letters. 421:277-279, 1998.
- Lin J et al. Chemoprevention of cancer and cardiovascular disease by resveratrol.
Proceedings of the National Science Council Republic of China. 23(3):99-106, 1999. Review.
- Manna S et al. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappaB, activator protein-1 and apoptosis: potential role of oxygen intermediates and lipid peroxidation. Journal of Immunology. 164(12):6509-6516, 2000.
- Martín A et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochemical Pharmacology. 67(7):1399-410, 2004.
- Martín A et al. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. British Journal of Pharmacology. 147(8):873-85, 2006.
- Martinez J and Moreno J. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochemical Pharmacology. 59:865-870, 2000.
- Mgbonyebi O. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. International Journal of Oncology. 12(4):865-869, 1998.
- Nielsen M et al. Resveratrol reverses tumor-promoter-induced inhibition of gap-junctional intercellular communication. Biochemical and Biophysical Research Communications. 275:804-809, 2000.
- Olas B and Wachowicz B. Resveratrol and vitamin C as antioxidants in blood platelets. Thrombosis Research. 106(2):143-8, 2002.
- Olas B and Wachowicz B. Resveratrol reduces oxidative stress induced by platinum compounds in blood platelets. General Physiology and Biophysics. 23(3):315-26, 2004.
- Olas B et al. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thrombosis Research. 107(3-4):141-5, 2002.
- Olas B et al. Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cellular and Molecular Biology Letters. 9(4A):577-87, 2004.
- Pace-Asciak C et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 235:207-219, 1995
- Picard F et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 429(6993):771-776, 2004.
- Porcu M et al. The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. Trends in Pharmacological Sciences 26, 2005.
- Pozo-Guisado, E., et al. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. International Journal of Cancer 115(1):74-84, 2005.
- Provinciali M et al. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International Journal of Cancer. 115(1):36-45, 2005.
- Sato M et al. Journal of Cardiovascular Pharmacology. 35(2):263-268, 2000.
- Schneider Y et al. Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Letters. 158(1):85-91, 2000.
- Sinclair D et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 2006.
- Sovak M. Grape extract, resveratrol, and its analogs: a review. Journal of Medicinal Food. 4(2):93-105, 2001.
- Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. Journal of Biological Chemistry. 273:21875-21882, 1998.
- Subbaramaiah K et al. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Annal NY Academy Sciences. 889:214-223, 2000.
- Szende B et al. Dose-dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures. Experimental and Molecular Medicine. 32(2):88-92, 2000.
- Tsai S et al. Suppression of nitric oxide synthase and the down-regulation of the activation of NF-kappaB in macrophages by resveratrol. British Journal of Pharmacology 126:673-680, 1999.
- Wang Z et al. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. International Journal of Molecular Medicine. 9(1):77-9, 2002.
- Yi W et al. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. Journal of Agricultural and Food Chemistry 53(18):7320-9, 2005.
- Zou J et al. Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med. 11(3):317-20, 2003.
- Zou J et al. Suppression of mitogenesis and regulation of cell cycle traverse by resveratrol in cultured smooth muscle cells. International Journal of Oncology. 15:647-651, 1999.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.